Take oxycodone and acetaminophen tablets exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed. • For acute (short-term) pain, you may only need to take oxycodone and acetaminophen tablets for a few days. Do not take Oxycodone and Acetaminophen Tablets if you have: Severe asthma, trouble breathing, or other lung problems. A bowel blockage or have narrowing of the stomach or intestines. Known hypersensitivity to oxycodone, acetaminophen, or any ingredient in Oxycodone and Acetaminophen Tablets. This information from UpToDate Lexidrug TM explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. This drug has an opioid drug in it. Opioid drugs can put you at risk for drug use disorder. Oxycodone is excreted in breast milk in low concentrations, and there have been rare reports of somnolence and lethargy in babies of nursing mothers taking an oxycodone/acetaminophen product. Do not take Oxycodone and Acetaminophen Tablets if you have: Severe asthma, trouble breathing, or other lung problems. A bowel blockage or have narrowing of the stomach or intestines. known hypersensitivity to oxycodone, acetaminophen, or any ingredient in Oxycodone and Acetaminophen Tablets. Oxycodone and Acetaminophen is available in tablets for oral administration. The tablets contain pregelatinized corn starch, crospovidone, povidone, magnesium stearate, colloidal silicon dioxide, and stearic acid. When you first start taking Oxycodone and Acetaminophen Tablets, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur.